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Mitochondrial flashes regulate ATP homeostasis in the heart
Xianhua Wang et al.
Mitochondrial flashes counteract the imbalance of ATP supply-and-demand and constitute an auto-regulator of ATP homeostasis in the heart.
A novel ALS-associated variant in
regulates motor axon morphogenesis
Brittany M Edens et al.
A novel ALS-associated variant in UBQLN4 impairs proteasome function and beta-catenin degradation to drive aberrant axon morphogenesis in motor neurons.
Chromosomes and Gene Expression
ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion
Wei-Ta Chen et al.
The ATM kinase has an unanticipated role in tumor progression through the regulation of cell migration by oxidative stress.
The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress
Qi Zhang et al.
The small molecule Inauhzin possesses a dual targeting ability, and activates p53 by targeting two enzymes—SIRT1 and IMP dehydrogenase 2 (IMPDH2)—which are highly expressed in human cancers.
The yeast H
-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H
-coupled nutrient uptake
Elie Saliba et al.
The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast
Dendritic mitochondria reach stable positions during circuit development
Michelle C Faits et al.
Mitochondria reach stable positions in dendrites during a critical developmental period of high motility.
Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9
Barbara Commisso et al.
The projections from discrete areas to motor cortex increase over disease course in motoneuron disease model with selective spatial and temporal patterns.
Computational and Systems Biology
Structural Biology and Molecular Biophysics
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
Jamie A Macpherson et al.
Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.
Biochemistry and Chemical Biology
Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca
Jing Yong et al.
ATP enters the endoplasmic reticulum (ER) lumen through an SLC35B1/AXER-dependent
mechanism, and ATP usage in the ER renders 'anti-
' effect by increasing ATP regeneration from OxPhos while decreasing glycolysis.
ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
Amy J Curwin et al.
The release of Acb1 protein from yeast cells requires the ESCRT-III complex to stabilize the compartment for unconventional protein secretion (CUPS).
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