2,385 results found
    1. Cell Biology
    2. Cancer Biology

    Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

    Keren Yizhak et al.
    Genome-scale metabolic modeling of individual cancer cells and healthy human cells identifies specific and selective metabolic vulnerabilities.
    1. Chromosomes and Gene Expression

    Dominant drug targets suppress the emergence of antiviral resistance

    Elizabeth J Tanner et al.
    When antiviral compounds target oligomeric assemblages, the formation of chimeric oligomers within cells can negate selection for naturally occurring drug-resistant variants.
    1. Microbiology and Infectious Disease

    HIV in Women: How HIV exploits T cells in the endometrium

    Marta Rodriguez-Garcia
    Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Bacterial Evolution: The road to resistance

    Devon M Fitzgerald
    The way that bacteria grow—either floating in liquid or attached to a surface—affects their ability to evolve antimicrobial resistance and our ability to treat infections.
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    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
    1. Cancer Biology

    Breast Cancer: Targeting mutant estrogen receptors

    Suzanne E Wardell et al.
    A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
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    1. Neuroscience

    Computational Psychiatry: Exploring atypical timescales in the brain

    Leonardo L Gollo
    Identifying activity imbalances in specific brain regions may help to diagnose and treat psychiatric disorders.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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