131 results found
    1. Cell Biology

    ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins

    Lu Zhu et al.
    The lysosome membrane is a new functional location for the ESCRTs in yeast.
    1. Developmental Biology

    Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Wipawee Winuthayanon et al.
    Cyclic estrogen signaling in oviduct epithelial cells suppresses oviduct luminal protease activity to allow survival and development of preimplantation embryos
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

    Blake W Tye et al.
    Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.
    1. Ecology

    Dynamic metabolic exchange governs a marine algal-bacterial interaction

    Einat Segev et al.
    Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.
    1. Cell Biology

    Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

    Mirko Messa et al.
    Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

    Timothy J Wendorff, James M Berger
    The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.
    1. Plant Biology

    Phloem unloading in Arabidopsis roots is convective and regulated by the phloem-pole pericycle

    Timothy J Ross-Elliott et al.
    A study of solute and macromolecule trafficking in plants reveals a previously undescribed route for carbon distribution in growing root tissues.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

    Jason G Dumelie, Samie R Jaffrey
    Genome-wide profiling of R-loops at near single-nucleotide resolution reveals distinct R-loop boundaries depending on the presence and location of the first exon-intron junction.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

    Qi Wang et al.
    A key B-cell tyrosine kinase that adopts an autoinhibited conformation, and can be activated by either membrane recruitment or soluble inositol hexakisphosphates in solution.
    1. Cell Biology
    2. Human Biology and Medicine

    A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

    Mira I Pronobis et al.
    A new dynamic mechanistic model explains how the destruction complex negatively regulates Wnt signaling in development and oncogenesis.

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