248 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

    Jerome C Nwachukwu et al.
    Anti-inflammatory effects of resveratrol are mediated by the estrogen receptor to coordinate a complex array of transcriptional coregulators, suggesting that estrogenic effects must be considered in the complex polypharmacology of resveratrol.
    1. Structural Biology and Molecular Biophysics

    Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

    Sean W Fanning et al.
    Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
    1. Neuroscience

    Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment

    Yanan Chen et al.
    Oligodendrocytes with an enhanced ability to withstand cytotoxic stress display an increased capacity to remyelinate demyelination lesions of the CNS in the presence of an inflammatory environment.
    1. Structural Biology and Molecular Biophysics

    Breast Cancer: How drug resistance takes shape

    Rinath Jeselsohn, Myles Brown
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    1. Cancer Biology

    Breast Cancer: Targeting mutant estrogen receptors

    Suzanne E Wardell et al.
    A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
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    1. Immunology and Inflammation

    Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

    Marie Marotel et al.
    Similar to T cell exhaustion, natural killer cell dysfunction in chronic hepatitis B patients results from deregulated calcium pathway.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Cancer Biology
    2. Neuroscience

    Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice

    Zhi Zhang et al.
    Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional properties of CALHM channels of the human placenta

    Katarzyna Drożdżyk et al.
    Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
    1. Developmental Biology
    2. Genetics and Genomics

    An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

    Bryan A Martinez et al.
    A truncated, non-signaling insulin receptor regulates insulin sensitivity in the nematode C. elegans by sequestering insulin peptides and preventing their interaction with full length receptors.

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