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A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.

Detailed molecular profiling investigations alongside antitumor testing and tolerability studies in animals suggest caution when considering the clinical development of inhibitors of CDK8 and CDK19, since a clear therapeutic window could not be demonstrated with two structurally distinct, potent and selective prototype drugs.

A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.

Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.

Protein aggregates resulting from mutations in C9orf72 impair different aspects of cellular quality control in the cytosol and the nucleus, but mRNA-mediated effects contribute more strongly to toxicity.

Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.

Pathogenesis in Spinocerebellar Ataxia Type 3 is enhanced by the heat-shock protein family member, Hsc70-4, uncovering new mechanisms of toxicity for this disease and suggesting pleiotropic roles for chaperones.

Xanthones produced by the filamentous fungus Aspergillus nidulans protect its sexual structures from predation by arthropods.

A cell-surface receptor called Gpr52 is able to lower the levels of the disease-causing protein mutant huntingtin and suppress its toxicity when knocked-down, making this receptor a promising drug target in Huntington's disease.

Specific tissue environments provide selective pressures that give rise to distinct Ras oncogenic dosage in primary liver tumours and their metastatic-like outgrowths.