Not all members of the bacteria sodium channel family are sodium channels - those found in Bacillus are highly adaptable and can be converted into many selectivity types.
Sebastian Molina-Obando, Juan Felipe Vargas-Fique ... Marion Silies
A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
Anchoring of grid firing fields to task environments is consistent with roles specifically in path integration rather than spatial localisation in general.
Prerna Srivastava, Geoff de Rosenroll ... Gautam Bhagwan Awatramani
Two-photon glutamate imaging reveals that 'sustained' and 'transient' input are systematically arranged along single starburst dendrites, supporting the 'space-time' wiring model for direction selectivity.
A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
Jonathan Martinez-Fabregas, Stephan Wilmes ... Ignacio Moraga
Engineering cytokines to exhibit different receptor binding dwell times is a useful strategy to decouple their functional pleiotropy and reduce their toxicity in the clinic.
Konstantinos-Evangelos Petousakis, Jiyoung Park ... Panayiota Poirazi
Apical and basal dendrites contribute differently to single-neuron orientation selectivity, highlighting the impact of feedforward and feedback signal interactions.
Kenichi Shimada, John A Bachman ... Timothy J Mitchison
shinyDepMap helps users explore the essentiality, selectivity, and function of the genes across hundreds of cancer cell lines and identify cancer drug targets.
