78 results found
    1. Developmental Biology
    2. Neuroscience

    Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function

    Yinan Li, Anthony Osuma ... Paschalis Kratsios
    The terminal selector-type transcription factor UNC-3/Ebf partially modifies the suite of its target genes at different life stages to establish and maintain the identity of C. elegans motor neurons.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.
    1. Neuroscience

    The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons

    Emily G Berghoff, Lori Glenwinkel ... Oliver Hobert
    Circuit transcription factors may define the differentiation and assembly of distinct neurons into functional circuitry.
    1. Neuroscience

    In silico analysis of the transcriptional regulatory logic of neuronal identity specification throughout the C. elegans nervous system

    Lori Glenwinkel, Seth R Taylor ... Oliver Hobert
    Neuron type-specific gene batteries share cis-regulatory motifs.
    1. Developmental Biology
    2. Neuroscience

    A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing

    Wei-Ming Yu, Jessica M Appler ... Lisa V Goodrich
    Genetic studies in mice identify the transcription factor MafB as a potent regulator of specific features of the synapses underlying hearing.
    1. Developmental Biology

    Developmental compartments in the larval trachea of Drosophila

    Prashanth R Rao, Li Lin ... Thomas B Kornberg
    Cells in the tracheal systems of fruit fly larvae are organised into compartments with precisely located boundaries, which pattern the formation of branched tubular networks.
    1. Developmental Biology

    Mamo decodes hierarchical temporal gradients into terminal neuronal fate

    Ling-Yu Liu, Xi Long ... Tzumin Lee
    Neuronal diversity is expanded by a temporal fating paradigm utilizing hierarchical gene regulation.
    1. Neuroscience

    An intersectional gene regulatory strategy defines subclass diversity of C. elegans motor neurons

    Paschalis Kratsios, Sze Yen Kerk ... Oliver Hobert
    Genetic analysis reveals the mechanistic basis of motor neuron subclass specification in Caenorhabditis elegans.
    1. Developmental Biology
    2. Neuroscience

    A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life

    Weidong Feng, Yinan Li ... Paschalis Kratsios
    A molecular mechanism that involves highly conserved transcription factors enables cholinergic motor neurons of the nematode Caenorhabditis elegans to become and remain functional.
    1. Neuroscience

    The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34

    Berta Vidal, Burcu Gulez ... Oliver Hobert
    Genetic analysis reveals the molecular logic of specifying and maintaining the enteric nervous system of the nematode Caenorhabditis elegans.

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