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    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang, William C Spencer ... Evan S Deneris
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.
    1. Developmental Biology
    2. Physics of Living Systems

    Mechanism of life-long maintenance of neuron identity despite molecular fluctuations

    Joleen JH Traets, Servaas N van der Burght ... Jeroen S van Zon
    Differential binding kinetics of a master regulator to its target promoters can prevent spontaneous cell fate loss in a Caenorhabditis elegans neuron whose fate is controlled by a reversible switch.
    1. Developmental Biology

    Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    The homeodomain protein Bsh increases lamina neuron types and visual function.
    1. Developmental Biology
    2. Neuroscience

    Neuronal cell fate diversification controlled by sub-temporal action of Kruppel

    Johannes Stratmann, Hugo Gabilondo ... Stefan Thor
    A combination of temporal and sub-temporal genes combine to move the stem cell through different competence windows to generate different cell types at different time-points in Drosophila.
    1. Developmental Biology

    Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types

    Chundi Xu, Tyler B Ramos ... Chris Q Doe
    Notch signaling specifies binary neuronal fates through its integration with primary homeodomain activity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

    Emilia Dimitrova, Takashi Kondo ... Robert J Klose
    The ZF-CxxC protein FBXL19 recruits kinase-associated Mediator to CpG islands of silent developmental genes in embryonic stem cells, which primes these genes for activation during differentiation and is required for embryonic development.
    1. Developmental Biology
    2. Neuroscience

    Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

    Catarina Catela, Yihan Chen ... Paschalis Kratsios
    Molecular, genetic, and behavioral assays in mice establish a new role for Hox proteins in the final steps of spinal motor neuron development.
    1. Neuroscience

    Timing mechanism of sexually dimorphic nervous system differentiation

    Laura Pereira, Florian Aeschimann ... Oliver Hobert
    The timing of sexual differentiation in the brain of the nematode Caenorhabditis elegans is controlled by a phylogenetically conserved pathway of gene regulatory factors.
    1. Developmental Biology
    2. Neuroscience

    Lmx1b is required at multiple stages to build expansive serotonergic axon architectures

    Lauren J Donovan, William C Spencer ... Evan S Deneris
    A continuously expressed LIM HD factor, Lmx1b, acts at successive stages to orchestrate the progressive morphological maturation of a long-range profusely arborized neuromodulatory axonal projection pathway.
    1. Developmental Biology
    2. Evolutionary Biology

    Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity

    Ethan Ozment, Arianna N Tamvacakis ... Nagayasu Nakanishi
    Developmental genetics of sea anemone mechanosensory neurons provides insights into the deep evolutionary history of mechanoreceptor development in animals.