1,407 results found
    1. Physics of Living Systems

    Stochastic yield catastrophes and robustness in self-assembly

    Florian M Gartner et al.
    Fluctuations in the availability of particles for binding can completely jeopardize yield in heterogeneous self-assembly.
    1. Cell Biology

    De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

    Won-Jing Wang et al.
    Canonical centriole duplication is much less prone to errors than de novo synthesis of centrioles, but neither depends on self-oligomerization of the centriole protein SAS-6.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Zebrafish embryonic explants undergo genetically encoded self-assembly

    Alexandra Schauer et al.
    Blastoderm tissue organization and patterning in zebrafish explants is driven by a genetically encoded and controlled self-assembly mechanism, rather than a bonafide self-organization mechanism.
    1. Cell Biology

    Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

    Jan-Erik Hoffmann et al.
    In the cytosol, the proteins constituting cell-matrix adhesion sites form multi-protein building blocks which enter and leave these sites unaltered, thereby contributing to their rapid and correct self-assembly.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Many-molecule encapsulation by an icosahedral shell

    Jason D Perlmutter et al.
    Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    tRNA sequences can assemble into a replicator

    Alexandra Kühnlein et al.
    Rudimentary cross-catalytic replication can be established by double-hairpins of tRNA-like sequences, implying that replication and translation could have emerged along a common evolutionary trajectory.
    1. Cell Biology
    2. Physics of Living Systems

    Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

    Anjali Jaiman, Mukund Thattai
    By partitioning promiscuous enzymes across multiple Golgi compartments, eukaryotic cells can tightly control the synthesis of complex sugar oligomers.
    1. Physics of Living Systems

    Shape selection and mis-assembly in viral capsid formation by elastic frustration

    Carlos I Mendoza, David Reguera
    Nucleation, elasticity theory, and simulations were combined to construct a general phase diagram that elucidates the conditions for successful viral assembly and the key factors to prevent it.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication

    Iris V Hood, James M Berger
    A phage-encoded protein inhibits a bacterial replicative helicase loading factor by exploiting an internal site that auto-regulates loader self-assembly and ATPase activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson et al.
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.

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