634 results found
    1. Neuroscience

    Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop

    Pablo Ripollés et al.
    Self-motivated learning in the absence of external feedback can recruit the same brain network as reward-driven learning.
    1. Neuroscience

    Uncovering the functional anatomy of the human insula during speech

    Oscar Woolnough et al.
    Direct insular recordings in humans reveal that contrary to several prominent models of speech production, it is not engaged in pre-articulatory planning, but in auditory and somatosensory components of speech.
    1. Neuroscience

    Response-based outcome predictions and confidence regulate feedback processing and learning

    Romy Frömer et al.
    Computational modeling, and empirical behavioral and EEG results show that learning relies not only on comparing current events to past experience, but integrates response-based outcome predictions and confidence.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cross-talk between individual phenol-soluble modulins in Staphylococcus aureus biofilm enables rapid and efficient amyloid formation

    Masihuz Zaman, Maria Andreasen
    Inter-molecular cross-seeding between phenol-soluble modulins facilitates rapid and efficient self-assembly in Staphylococcus aureus biofilms revealing a complex molecular interplay between distinct phenol-soluble modulins orchestrating functional amyloid formation.
    1. Structural Biology and Molecular Biophysics

    A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

    Daiane S Alves et al.
    The transmembrane domain of the EphA2 receptor has been transformed into a novel amphitropic peptide that binds to the EphA2 receptor and inhibits cell migration.
    1. Neuroscience

    Distinct neural contributions to metacognition for detecting, but not discriminating visual stimuli

    Matan Mazor et al.
    Combining psychophysics and functional MRI reveals a qualitative asymmetry in neural engagement when reflecting on whether a stimulus is seen (detection) compared to reflecting on what a stimulus is (discrimination).
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell et al.
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
    1. Neuroscience

    Different contributions of preparatory activity in the basal ganglia and cerebellum for self-timing

    Jun Kunimatsu et al.
    Neuronal activity in the striatum keeps track of elapsed time during the time production task while that in the cerebellum correlates with stochastic variation of self-timing in the range of several hundreds of milliseconds.
    1. Structural Biology and Molecular Biophysics

    Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

    Geoff P O'Donoghue et al.
    Quantitative observations of single-molecule binding between antigen and T cell receptor (TCR) in living primary T cells reveals unbinding kinetics, stoichiometry and signaling molecule recruitment, providing insights into the mechanisms of antigen recognition by the immune system.
  1. Research: United States National Postdoc Survey results and the interaction of gender, career choice and mentor impact

    Sean C McConnell et al.
    The quality of mentoring received while a postdoc influences career choice irrespective of field, gender, or ethnicity, according to a 7,603-respondent postdoc survey.

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