1,701 results found
    1. Neuroscience

    Human motor fatigability as evoked by repetitive movements results from a gradual breakdown of surround inhibition

    Marc Bächinger et al.
    Motor fatigability is associated with a decrease in inhibition throughout the motor network, suggesting that selective inhibitory control is a key mechanism to maintain motor efficiency during repetitive movements.
    1. Developmental Biology
    2. Evolutionary Biology

    The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal

    Lotta Salomies et al.
    Analysis of bearded dragon model reveals a novel tooth replacement strategy that demonstrates the critical importance of epithelial patterning, cell migration, and putative stem cell functional specialization in tissue regeneration.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Extensive ribosome and RF2 rearrangements during translation termination

    Egor Svidritskiy et al.
    Ensemble cryo-EM visualizes how structural rearrangements poise the newly made protein and release factor RF2 to dissociate in preparation for ribosome recycling.
    1. Ecology

    Entomopathogenic nematodes increase predation success by inducing cadaver volatiles that attract healthy herbivores

    Xi Zhang et al.
    By changing the smell of their host, entomopathogenic nematodes attract future hosts and increase their predation success.
    1. Neuroscience

    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

    Oleksandr Yagensky et al.
    Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander et al.
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Developmental Biology

    Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness

    Jordi Cayuso et al.
    Boundary cell identity and sharpening of borders are coupled in hindbrain development since both are regulated by mechanical tension.
    1. Microbiology and Infectious Disease

    Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome

    Kevin J Forsberg et al.
    A high-throughput, activity-based selection identifies many phage-derived inhibitors of Cas9 from human fecal and oral metagenomes, with at least one inhibitor acting via a novel mechanism.
    1. Neuroscience

    Processing of different spatial scales in the human brain

    Michael Peer et al.
    When subjects perform spatial judgments in environments of increasing scale, brain activity shifts along posterior-anterior gradients, advancing from the visual system to the default-mode network.
    1. Evolutionary Biology

    Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo

    Andrew M Taverner et al.
    Genome engineering and phenotyping in vivo reveal surprising new features of adaptive amino acid substitutions that were previously inaccessible.

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