Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.

Stem cell heterogeneity is progressively built in proliferating population by the action of mitochondrial glutamine metabolism that opposes the cell cycle-linked self-renewal network to generate differentiation-competent progenitors.

Stem cell self-renewal strategies fall into two classes, and only strategies of different classes can be experimentally distinguished via static clonal data.

The niche signal that ensures stem cells self-renew appropriately has been identified in the midgut of Drosophila.

A set of ex vivo and in vivo experiments, including genetic ablation and regeneration studies, identify a key regulatory function of SOXF factors in muscle stem cells in mice.

In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.

Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

The specification of cell polarity is essential for self-renewal and the segregation of stem-cell and daughter-cell fates in an epithelial stem cell lineage.

Adult microglia are born by the division of single surviving microglia that rapidly acquire mature morphologies and functions in order to perform their physiological roles in the brain.

The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.