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6,972 results found
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Structural mechanism of ligand activation in human calcium-sensing receptor

    Yong Geng et al.
    L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer et al.
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Neuroscience

    A selective effect of dopamine on information-seeking

    Valentina Vellani et al.
    L-DOPA administration increases information-seeking about potential losses without impacting information-seeking about potential gains, and as a result, it reduces the effect of valence on information-seeking.
    1. Neuroscience

    Neural activity in a hippocampus-like region of the teleost pallium is associated with active sensing and navigation

    Haleh Fotowat et al.
    Sparse firing in a hippocampus-like structure of the teleost telencephalon is linked to spatial navigation and active sensing.
    1. Developmental Biology
    2. Evolutionary Biology

    Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

    Juan Jose Fraire-Zamora et al.
    Evolutionary reduction in tissue number involves the simplification of the seaming process but not signaling during epithelial fusion.
    1. Ecology
    2. Evolutionary Biology

    Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community

    Samuel Frederick Mock Hart et al.
    Whereas partner-serving phenotype is intuitively quantified as benefit release rate, molecular genetics revealed an example where this thinking fails, motivating a more general metric.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity

    Nate Yoder, Eric Gouaux
    The amino terminus of acid-sensing ion channel 1a forms a reentrant 'loop' that frames the lower pore and harbors a conserved 'His-Gly' motif implicated in gating and ion selectivity mechanisms.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring et al.
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Physics of Living Systems

    Ligand sensing enhances bacterial flagellar motor output via stator recruitment

    Farha Naaz et al.
    Sensing of ligands by chemoreceptors of Escherichia coli not only causes changes in the rotational bias of the flagellar motors but also increases motor speed via temporary recruitment of stators.
    1. Physics of Living Systems

    Theory for the optimal detection of time-varying signals in cellular sensing systems

    Giulia Malaguti, Pieter Rein ten Wolde
    A theory is presented for the optimal design of cellular sensing systems that maximizes the sensing precision given resource constraints.

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