Following anterior temporal lobe neurodegeneration, defective semantic representations are compensated via enhanced perceptual processing and associated with a dysregulation of the semantic control system.
OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.
Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.
Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.
A novel methodical approach aimed at improving translation of network analyses to psychopathology provides an intuitive representation of longitudinal clinical pathways between symptoms and can assist in predicting prognosis.