Remaining focused on the topic at hand when speaking depends on effective selection of task-relevant semantic knowledge, and declines in this ability account for increases in off-topic speech in older people.
LRRK2 G2019S knock-in mice are a genetically faithful model that recapitulates the slow disease progression of familial PD, with initial alterations to behaviour and neurotransmission providing early pathophysiological targets for neuroprotective interventions.
Computer simulations of the evolution of broadly neutralizing antibodies against HIV suggest that non-traditional pathways involving framework mutations which lead initially to increased antibody flexibility do occur, but can be avoided by appropriate vaccine design.
A separation-of-function mutation reveals that a niche ligand receptor Dome functions in spindle orientation during asymmetric stem cell division by directly binding to Eb1, independent of its role in downstream JAK-STAT signaling.
Spontaneous theta oscillations and interneuron-specific phase preferences emerge spontaneously in a full-scale model of the isolated hippocampal CA1 subfield, corroborating and extending recent experimental findings.