364 results found
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki et al.
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
    1. Genetics and Genomics

    Germline burden of rare damaging variants negatively affects human healthspan and lifespan

    Anastasia V Shindyapina et al.
    Rare highly damaging mutations that are present in most human genomes decrease lifespan and are associated with an earlier onset of chronic diseases.
    1. Neuroscience

    Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia

    V Borghesani et al.
    Following anterior temporal lobe neurodegeneration, defective semantic representations are compensated via enhanced perceptual processing and associated with a dysregulation of the semantic control system.
    1. Cancer Biology
    2. Developmental Biology

    Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation

    Erin A Bassett et al.
    The earliest steps of tumor initiation in the cerebellum are regulated by critical interactions between pre-tumor cells and stromal cells, which can be manipulated by targeting the Norrin/Frizzled4 signaling axis.
    1. Neuroscience

    Integrative frontal-parietal dynamics supporting cognitive control

    Derek Evan Nee
    Analysis of human fMRI data reveal that intermediary areas within the fronto-parietal control network (FPCN) are critical for integrating control processing, cognitive ability, and amenability to neuromodulation.
    1. Neuroscience

    Neural encoding of actual and imagined touch within human posterior parietal cortex

    Srinivas Chivukula et al.
    Single neurons in human posterior parietal cortex encode actual and imagined touch within a shared neural substrate.
    1. Neuroscience

    Synaptic plasticity through activation of GluA3-containing AMPA-receptors

    Maria C Renner et al.
    A novel form of hippocampal synaptic plasticity is expressed by a change in channel function of GluA3-containing AMPA-receptors.
    1. Neuroscience

    Integrative and distinctive coding of visual and conceptual object features in the ventral visual stream

    Chris B Martin et al.
    Perirhinal cortex, a brain structure located in the medial temporal lobe, uniquely supports the integration of visual and conceptual object information.
    1. Developmental Biology
    2. Evolutionary Biology

    Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

    Luca Livraghi et al.
    The evolution of a butterfly mimetic phenotype is driven by modular cis-regulstory switches controlling a ‘hotspot’ gene.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

    Christopher T Boughter et al.
    A new software developed for high-throughput antibody, T cell receptor, and MHC repertoire analysis uncovers neutrality of the binding interface and intramolecular crosstalk as distinguishing properties of polyreactive antibodies.

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