242 results found
    1. Neuroscience

    A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

    Yangyu Wu et al.
    Three residues work together as a valve-like mechanism to control desensitization from pre-open and open states in the ion channels ASIC1a, ASIC2a, and ASIC3.
    1. Neuroscience

    Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila

    Seol Hee Im et al.
    The Drosophila equivalent of Substance P signaling modulates nociceptive sensitization by regulating Hedgehog signaling within nociceptive sensory neurons.
    1. Structural Biology and Molecular Biophysics

    Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel

    Ailing Tong et al.
    Phosphatidylglycerol binding at multiple sites stabilizes the open state relative to the desensitized state of a pentameric ligand-gated ion channel.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

    Anthony W Azevedo et al.
    Serine and threonine phosphorylation sites work in concert to provide rapid and reproducible desensitization of the G-protein coupled receptor rhodopsin.
    1. Neuroscience

    Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium

    Stephanie C Gantz et al.
    The loss of calcium-dependent D2 autoreceptor desensitization caused by prior in vivo cocaine exposure may be conferred by an unexpected role of the D2L splice variant as an autoreceptor.
    1. Neuroscience

    Cellular tolerance at the µ-opioid receptor is phosphorylation dependent

    Seksiri Arttamangkul et al.
    The role of C-terminal phosphorylation is critical for the expression of acute desensitization, trafficking and long-term tolerance to morphine.
    1. Neuroscience

    Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

    Brooks G Robinson et al.
    Desensitization of the D2 autoreceptor is reduced following in vivo cocaine exposure due to plasticity in the D2S and not the D2L splice variant.
    1. Neuroscience

    Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin

    Mouloud Bouhadfane et al.
    The pain mediator bradykinin was found to sensitize spinal motoneurons by a direct postsynaptic action, questioning the role of motoneurons in the assessment of hyperalgesia since the withdrawal motor reflex is commonly used as a surrogate pain model.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Auxiliary subunits keep AMPA receptors compact during activation and desensitization

    Jelena Baranovic, Andrew JR Plested
    The auxiliary protein Stargazin limits the conformational dynamics of AMPA-type glutamate receptors in cell membranes, as revealed by 'molecular rulers' deployed on the seconds to milliseconds timescale.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

    Irene Riva et al.
    Glutamate receptor auxiliary proteins exert their effects on receptor gating through two divergent extracellular loops, explaining subunit specificity and allowing the construction of null versions that form complexes normally but do not modify receptor gating.

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