2,341 results found
    1. Neuroscience

    Temporal selectivity declines in the aging human auditory cortex

    Julia Erb et al.
    The aged human auditory cortex shows preserved tonotopy, but temporal modulations are represented with a markedly broader tuning, highlighting decreased temporal selectivity as a hallmark of the aging auditory cortex.
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

    Michael R Garvin et al.
    Gene expression analysis reveals a novel, integrated molecular mechanism for much of the pathogenesis of COVID-19 that provides therapeutic intervention points that can be addressed with existing approved pharmaceuticals.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis

    Tyler Wagner et al.
    Applying deep learning technology for the large-scale curation of symptoms from unstructured EHR clinical notes accurately predicts the differential signals of COVID-19 diagnosis over the week preceding typical PCR testing.
    1. Microbiology and Infectious Disease

    Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

    Giancarlo Noe Bruni, Joel M Kralj
    Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
    1. Computational and Systems Biology
    2. Neuroscience

    A sensorimotor model shows why a spectral jamming avoidance response does not help bats deal with jamming

    Omer Mazar, Yossi Yovel
    An elaborated bat-predator model shows that even in high bat-densities, bats can successfully catch flying insects and that changing their signals’ frequency is not necessary for dealing with sensory interference.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Ecology

    Biodiversity mediates the effects of stressors but not nutrients on litter decomposition

    Léa Beaumelle et al.
    The consequences of real-world biodiversity change for ecosystem functioning depend on the type of global change driver and can be particularly significant when human activities decrease biodiversity.
    1. Human Biology and Medicine
    2. Neuroscience

    Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

    Stavros Trakoshis et al.
    Excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic males versus females.
    1. Neuroscience

    Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

    Lisa R Beutler et al.
    Neurons that promote hunger become desensitized to dietary fat in obesity.
    1. Neuroscience

    Boosts in brain signal variability track liberal shifts in decision bias

    Niels A Kloosterman et al.
    Modulation of moment-to-moment irregularity of neural activity closely tracks our ability to flexibly adapt decision biases to the environment.

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