3,007 results found
    1. Developmental Biology

    A phenotypic screening platform utilising human spermatozoa identifies compounds with contraceptive activity

    Franz S Gruber et al.
    A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

    Eugenia Lyashenko et al.
    Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.
    1. Neuroscience

    Damage to the right insula disrupts the perception of affective touch

    Louise P Kirsch et al.
    Lesion analyses in right hemisphere stroke patients reveal the crucial role of the right anterior and posterior insula in the perception of affective touch.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni et al.
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Chromosomes and Gene Expression

    Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing

    Kazuki Saito et al.
    E. coli ribosomes incapable of base-pairing with the Shine-Dalgarno sequence are still selective for annotated start sites, indicating these sites are hard-wired for initiation by other mRNA features.
    1. Neuroscience

    Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

    Jingjing Sherry Wu et al.
    Based on the animal’s recent history of sound exposure, cholinergic auditory brainstem neurons dynamically regulate dopamine synthesis for inhibitory feedback to the inner ear.
    1. Neuroscience

    Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells

    Marina Garrett et al.
    VIP inhibitory neurons are active in response to novel images but are suppressed by familiar stimuli and show ramping activity when expected stimuli are omitted.
    1. Computational and Systems Biology
    2. Neuroscience

    Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

    Marco A Navarro et al.
    Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.
    1. Epidemiology and Global Health

    Estimating effectiveness of case-area targeted response interventions against cholera in Haiti

    Edwige Michel et al.
    Case-area targeted interventions conducted by rapid response teams appeared significantly effective to mitigate and shorten local cholera outbreaks in the Centre department of Haiti in 2015-2017.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence

    Takushi Shimomura et al.
    The small glycine residue in the Cav selectivity filter is an overlooked feature that determines Ca2+ selectivity and provides new insight into the Ca2+ selectivity mechanism conserved from prokaryotes to eukaryotes.

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