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    1. Neuroscience

    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

    Nicole Scholz et al.
    Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

    Geoffrey Gourinchas et al.
    Molecular insights to phytochrome activation and signal transduction over long distances enable the allosteric regulation of enzymatic effectors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva et al.
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Immunology and Inflammation

    A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

    Yasunobu Arima et al.
    Pain sensation induces relapse in a mouse model of multiple sclerosis via a sensory-sympathetic signaling pathway.
    1. Cell Biology
    2. Neuroscience

    The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

    Eun Chan Park, Christopher Rongo
    The subcellular localization of the prolyl hydroxylase oxygen sensor in C. elegans neurons is regulated by p38 MAP kinase signaling.
    1. Neuroscience

    Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

    Francie Moehring et al.
    Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
    1. Neuroscience

    A Toll-receptor map underlies structural brain plasticity

    Guiyi Li et al.
    Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.
    1. Neuroscience

    Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila

    Seol Hee Im et al.
    The Drosophila equivalent of Substance P signaling modulates nociceptive sensitization by regulating Hedgehog signaling within nociceptive sensory neurons.
    1. Developmental Biology
    2. Genetics and Genomics

    Neurogenesis: Silencing the alternative

    Priya Sivaramakrishnan, John Isaac Murray
    The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates in the nematode worm C. elegans.
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