1,356 results found
    1. Genetics and Genomics
    2. Neuroscience

    Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses

    John Lee, Kosuke Kawai ... Gwenaëlle SG Géléoc
    Genetic deficits in auditory sensory transduction evoke changes in development and maturation of synapses between inner hair cells and spiral ganglion neurons, which can be partially recovered using inner ear gene therapy.
    1. Neuroscience

    Excitatory and inhibitory synapse reorganization immediately after critical sensory experience in a vocal learner

    Ziqiang Huang, Houda G Khaled ... Richard HR Hahnloser
    Sensory acquisition of a motor target is associated with rapid removal of excitatory synapses and with rapid insertion of inhibitory synapses in the main song control area of songbirds.
    1. Developmental Biology
    2. Neuroscience

    Synaptic mitochondria regulate hair-cell synapse size and function

    Hiu-tung C Wong, Qiuxiang Zhang ... Katie Kindt
    Mitochondrial calcium influx plays distinct roles in presynapse formation, function and stability in sensory hair cells.
    1. Neuroscience

    Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs

    Samuel J Barnes, Georg B Keller, Tara Keck
    Following sensory deprivation in adult mice, homeostatic synaptic strengthening occurs in non-sensory network responsive synapses, but not in sensory responsive synapses, despite homeostatic increases to the global sensory-evoked responses.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen, Diancai Cai ... David L Glanzman
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Neuroscience

    Lamina-specific AMPA receptor dynamics following visual deprivation in vivo

    Han L Tan, Richard H Roth ... Richard L Huganir
    Longitudinal imaging of synapses in the brain shows that sensory deprivation differentially modifies specific synapses within individual neurons across distinct layers of the sensory cortex.
    1. Neuroscience

    ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition

    Sebastian Molina-Obando, Juan Felipe Vargas-Fique ... Marion Silies
    A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
    1. Developmental Biology
    2. Neuroscience

    Regulation of subcellular dendritic synapse specificity by axon guidance cues

    Emily C Sales, Emily L Heckman ... Chris Q Doe
    Axon guidance cues restrict sensory neuron synapse formation to a subset of equally acceptable interneuronal dendritic arbors during Drosophila locomotor circuit assembly.
    1. Neuroscience

    Thalamocortical synapses in the cat visual system in vivo are weak and unreliable

    Madineh Sedigh-Sarvestani, Larry A Palmer, Diego Contreras
    A characterization of LGN-V1 synaptic transmission properties demonstrates thalamocortical synapses in vivo are weak and unreliable, but biologically constrained models show they efficiently drive cortex.
    1. Neuroscience

    The wiring diagram of a glomerular olfactory system

    Matthew E Berck, Avinash Khandelwal ... Albert Cardona
    The complete neural circuit map of a tractable olfactory system will support studies towards bridging the gap between circuits and behavior.

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