3,139 results found
    1. Neuroscience

    Multiple time-scales of decision-making in the hippocampus and prefrontal cortex

    Wenbo Tang, Justin D Shin, Shantanu P Jadhav
    Hippocampal and prefrontal neuronal populations form slow behavioral-timescale (~seconds) and fast cognitive-timescale (~100 ms) sequential activity patterns as theta and replay sequences, which play distinct yet cooperative roles in memory-guided decision-making.
    1. Neuroscience

    Prefrontal-amygdalar oscillations related to social behavior in mice

    Nahoko Kuga, Reimi Abe ... Takuya Sasaki
    The dorsal medial prefrontal cortex and basolateral amygdala exhibit social behavior-relevant neuronal oscillations, representing unified pathophysiological mechanisms underlying social behavioral deficits.
    1. Neuroscience

    Functional cell types in the mouse superior colliculus

    Ya-tang Li, Markus Meister
    Neurons in the mouse superior colliculus comprise about 20 types based on their responses to visual stimuli, and neurons of the same type tend to cluster together.
    1. Neuroscience

    Large-scale replication study reveals a limit on probabilistic prediction in language comprehension

    Mante S Nieuwland, Stephen Politzer-Ahles ... Falk Huettig
    Large-scale replication study with brain potentials challenges the view that people routinely predict the phonological form of a predictable word during language comprehension.
    1. Cell Biology
    2. Genetics and Genomics

    NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling

    Malini Rajan, Cole P Anderson ... Elizabeth A Leibold
    Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..
    1. Cell Biology

    Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy

    Louise A Moyle, Eric Blanc ... Peter S Zammit
    Rescue of DUX4-induced muscle pathology by the RET inhibitor Sunitinib reveals the therapeutic potential for treatment of Facioscapulohumeral muscular dystrophy using tyrosine kinase inhibitors.
    1. Immunology and Inflammation

    NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

    Khursheed A Wani, Debanjan Goswamy ... Javier E Irazoqui
    Genetic and molecular characterization showed that evolutionarily conserved flavin-containing monooxygenase (FMO-2) plays an important role in host defense in Caenorhabditis elegans, and its induction is dependent on conserved transcription factors, TFEB and PPAR-α.
    1. Developmental Biology
    2. Neuroscience

    Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila

    Namrata Bali, Hyung-Kook (Peter) Lee, Kai Zinn
    The immunoglobulin superfamily cell surface protein Sticks and Stones is a binding partner for the Lar Drosophila receptor tyrosine phosphatase that mediates Lar's developmental functions at the larval neuromuscular junction, mushroom body, and adult optic lobe.
    1. Plant Biology

    PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis

    He Huang, Chan Yul Yoo ... Dmitri A Nusinow
    A conserved, circadian-regulated protein alters light perception in plants to regulate daily growth in response to changing photoperiod.
    1. Ecology

    Sequential phenotypic constraints on social information use in wild baboons

    Alecia J Carter, Miquel Torrents Ticó, Guy Cowlishaw
    Social information is a process encompassing information acquisition, application and exploitation that is constrained by an individual’s social, behavioural and demographic phenotype.

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