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    1. Cancer Biology

    ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

    Wentong Fang, Chengheng Liao ... Qing Zhang
    ZHX2 controls HIF1α oncogenic signaling and tumorigenesis in triple-negative breast cancer.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim, Soyeon Lim ... Jin Woo Kim
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Neuroscience

    Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

    Heidi IL Jacobs, Nikos Priovoulos ... Kâmil Uludağ
    By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin, Emily C Pierce, Rachel J Dutton
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Neuroscience
    2. Physics of Living Systems

    Stiffness and tension gradients of the hair cell’s tip-link complex in the mammalian cochlea

    Mélanie Tobin, Atitheb Chaiyasitdhi ... Pascal Martin
    The tip-link complex of the hair cell is mechanically tuned along the tonotopic axis of the cochlea.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees, Jun-Hai Yang ... Alain Karma
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
    1. Computational and Systems Biology
    2. Neuroscience

    A computationally informed comparison between the strategies of rodents and humans in visual object recognition

    Anna Elisabeth Schnell, Maarten Leemans ... Hans Op de Beeck
    Using a computational approach for designing object recognition tasks is beneficial to highlight the different strategies among different species.
    1. Developmental Biology

    Single-cell atlas of early chick development reveals gradual segregation of neural crest lineage from the neural plate border during neurulation

    Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
    A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
    1. Neuroscience

    A multisite validation of brain white matter pathways of resilience to chronic back pain

    Mina Mišić, Noah Lee ... Herta Flor
    The structural integrity of the right superior longitudinal fasciculus was identified as a neuroimaging predictor of chronic back pain, with potential for clinical translation.
    1. Neuroscience

    Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis

    Sergey D Stavisky, Francis R Willett ... Jaimie M Henderson
    Neurons in human dorsal motor cortex, an area involved in controlling arm and hand movements, are also active – and show similar ensemble dynamics – during speaking.