7,398 results found
    1. Evolutionary Biology

    Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

    Chenlu Di et al.
    Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.
    1. Neuroscience

    Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

    Zhe Zhang et al.
    Postnatal, postsynaptic loss of FMRP specifically weakens callosal synaptic inputs onto L2/3 pyramidal neurons, in requirement ofnormal sensory experience, through downregulating AMPA receptor transmission and without affecting local synaptic inputs during cortical circuit development.
    1. Medicine

    Modulation of fracture healing by the transient accumulation of senescent cells

    Dominik Saul et al.
    Senescent cells accumulate in the fracture callus and a reduction in the number of these cells accelerates fracture healing in mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

    Alessandro Bonfini et al.
    The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
    1. Cell Biology

    Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

    Laura Le Pelletier et al.
    Aging is associated with stress-induced senescence of adipose stromal cells, leading to impaired adipogenesis, oxidative stress, mitochondrial dysfunction, and insulin resistance, all being alleviated by metformin treatment of adipose stromal cells.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans

    Daniel Porto et al.
    Quantitative FRET imaging in moving C. elegans shows that stretch-unfolding of twitchin kinase occurs in the active muscle, whereby mechanical activity titrates the signaling pathway of this cytoskeletal kinase.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Competitive binding of MatP and topoisomerase IV to the MukB hinge domain

    Gemma LM Fisher et al.
    Topoisomerase IV and the ter-binding protein MatP competitively bind the hinge domain of the Escherichia coli Structural Maintenance of Chromosomes complex, MukB, leading to spatiotemporal regulation of MukBEF-topoisomerase IV activity.
    1. Cell Biology
    2. Developmental Biology

    Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

    Robert Becker et al.
    Myogenin promotes centrosome attenuation and establishes the nuclear envelope as the dominant microtubule organization center via the scaffold protein AKAP6, which is required for the recruitment of centrosomal proteins.
    1. Immunology and Inflammation

    Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

    Xiaoting Wu et al.
    Inducible fate-mapping analysis demonstrates that neither microglia, CD11c+ activated microglia nor border-associated macrophages are replenished by bone marrow-derived cells in Alzheimer’s disease.

Refine your results by:

Type
Research categories