2,965 results found
    1. Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson et al.
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
    1. Neuroscience

    Hippocampal place cells construct reward related sequences through unexplored space

    H Freyja Ólafsdóttir et al.
    In anticipation of a reward, hippocampal place cells simulate desired journeys through areas that have been seen, but not explored.
    1. Biochemistry and Chemical Biology

    Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition

    Clare Rollie et al.
    The acquisition of new foreign DNA by the prokaryotic adaptive immune system CRISPR-Cas is shown to depend on the fundamental sequence specificity of the Cas1 integrase.
    1. Evolutionary Biology

    Adaptation in protein fitness landscapes is facilitated by indirect paths

    Nicholas C Wu et al.
    The extra dimensions in protein sequence space open up indirect paths of adaptation and alleviate the constraint on the selective accessibility to high fitness genotypes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

    Ekaterina Morgunova et al.
    The epistasis observed in TF-DNA binding preferences can be explained by the presence of two optima of very similar Gibbs energy that are located relatively far from each other in sequence space.
    1. Microbiology and Infectious Disease

    Co-evolution within structured bacterial communities results in multiple expansion of CRISPR loci and enhanced immunity

    Nora C Pyenson, Luciano A Marraffini
    Cells must acquire multiple viral spacer sequences to neutralize mutant escaper phages and form colonies during the CRISPR-Cas immune response.
    1. Neuroscience
    2. Physics of Living Systems

    Replay as wavefronts and theta sequences as bump oscillations in a grid cell attractor network

    Louis Kang, Michael R DeWeese
    An experimentally supported model of grid cells naturally enables them to participate in firing sequences that encode rapid trajectories in space.
    1. Neuroscience

    Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model

    Jingheng Cheng, Daoyun Ji
    In a mouse model of neurodegeneration, hippocampal firing sequences that normally encode spatial memories become disengaged from external space.

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