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Ssl2 processivity determines the window for transcription start site selection during promoter scanning by RNA polymerase II in Saccharomyces cerevisiae.

A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.

Genome neighborhood networks provide an efficient large-scale approach to mine metabolic pathway context for entire families of proteins and enzymes.

Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.

Differing from its ortholog in Helicoverpa armigera, pheromone receptor HassOr14b is tuned to the major sex pheromone component in H. assulta, and two amino acids in the intracellular domain determine their ligand selectivity.

A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.

A novel species-sorting experiment finds that phylogenetically and functionally distinct microbial communities emerge under different temperature conditions due to the resuscitation of latent diversity.

A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.

6-Phosphogluconate dehydrogenase controls regulatory T cells metabolism with shifts to Th1, Th2, and Th17 phenotypes.

The short lifetime of orphan genes is a major factor explaining the stability of gene number in Drosophila.