Inspired by the sparse, sequential neural activity patterns observed in striatum, a new circuit model implements variable-speed activity, the encoding of multiple sequences, and a tutor/student relationship between cortex and striatum.
The consolidation of newly acquired motor skills induces a functional reorganization of sequential information representations within secondary motor cortex, basal ganglia and hippocampus.
Integrative structural biology reveals a conformational equilibrium in the Box C/D methylation enzyme that regulates the extent of site-specific 2'-O-rRNA methylation in dependence of the RNA sequence.
A new perception of the organization of T-cell receptor repertoires in mice and humans, based on high-throughput sequencing and CDR3 sequence similarity, indicates hubs of cross-species public sequences forming evolutionary conserved 'foci of attention' of T cell immunity.
Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
SeqZip is a new DNA ligation-based method to condense and maintain exon connectivity information within individual RNA molecules, which can provide new insights into alternative splicing.
Reporter-ChIP-nexus captures paused Pol II on transfected plasmids and shows that pausing stability is influenced by core promoter sequences, especially by the initiator with a G at +2 position.
CRISPR/Cas9 gene editing in mice reveals that diverse functions of actin isoforms are defined by their nucleotide, rather than their amino acid sequence, suggesting a novel mechanism of nucleotide-dependent protein regulation in eukaryotic genomes.
Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
