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    1. Microbiology and Infectious Disease

    Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus

    Juan-Carlos García-Betancur, Angel Goñi-Moreno ... Daniel Lopez
    During Staphylococcus aureus infections, bacterial cells bifurcate into distinct, specialized cell types that localize physically in different colonization tissues to simultaneously generate different infection types.
    1. Cell Biology

    Ribosomal composition affects the noncanonical translation and toxicity of polyglycine-containing proteins in fragile X-associated conditions

    Katarzyna Tutak, Izabela Broniarek ... Krzysztof Sobczak
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster, Rojin Chitrakar ... L Ryan Baugh
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci, Tiantian Zheng ... Edward A Lemke
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann, Caroline M Holmes, Mikhail Tikhonov
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)

    Michael J Rale, Brianna Romer ... Sabine Petry
    An evolutionarily conserved protein sequence present in diverse species like yeast, frogs, chickens, and humans binds a well-known template for microtubule nucleation, the gamma-tubulin ring complex, activating and enhancing its ability to nucleate microtubules, even under low tubulin concentrations.
    1. Cell Biology

    Genome concentration limits cell growth and modulates proteome composition in Escherichia coli

    Jarno Mäkelä, Alexandros Papagiannakis ... Christine Jacobs-Wagner
    Genome dilution limits cell growth by modulating the activities, rather than the concentrations, of RNA polymerases and ribosomes, and is accompanied by changes in proteome composition.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival

    Matthew Tien, Aretha Fiebig, Sean Crosson
    A gene network analysis approach reveals a conserved small regulatory RNA that is crucial for bacterial cell survival across distinct stress conditions.