3,093 results found
    1. Genetics and Genomics

    Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

    Eyal Ben-David et al.
    The effect of genetic variation on gene expression can be specific down to the level of individual cells.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

    Luke Stephen Tain et al.
    Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.
    1. Immunology and Inflammation

    Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

    Jinwei Chai et al.
    The novel cathelicidin cathelicidin-MH was identified from the skin of M. heymonsivogt frog, which protects against lipopolysaccharide- and cecal ligation and puncture-induced sepsis, effectively ameliorates multi-organ pathology, especially in lung.
    1. Cell Biology
    2. Medicine

    Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8

    Hsiang-Chun Chang et al.
    Mammalian cellular iron homeostasis and the maturation of the cytosolic iron sulfur cluster proteins are dependent on the mitochondrial protein import machinery.
    1. Developmental Biology

    Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion

    Naokazu Inoue et al.
    Mammalian fertilization is accomplished through integrating various molecular pathways that include evolutionarily conserved factors, DCST1 and DCST2.
    1. Microbiology and Infectious Disease

    Functional insights from a surface antigen mRNA-bound proteome

    Larissa Melo do Nascimento et al.
    A robust procedure to purify mRNAs and their associated proteins identify CFB2 as the critical protein that binds and influences the fate of the main virulence factor in Trypanosoma brucei.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

    Robert J Nichols et al.
    A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
    1. Cell Biology
    2. Neuroscience

    Neuronal junctophilins recruit specific CaV and RyR isoforms to ER-PM junctions and functionally alter CaV2.1 and CaV2.2

    Stefano Perni, Kurt Beam
    Neuronal junctophilins 3 and 4 similarly recruit and functionally modify P/Q and N-type calcium channels, but differentially recruit the three ryanodine receptor isoforms to endoplasmic reticulum-plasma membrane junctions.
    1. Microbiology and Infectious Disease

    Cerebrospinal fluid proteome maps detect pathogen-specific host response patterns in meningitis

    Anahita Bakochi et al.
    Statistical analysis and LASSO regression modeling provide insights into pathogen-specific host response patterns in cerebrospinal fluid from different disease etiologies to support future classification of pathogen type based on host response patterns in meningitis.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

    Yihu Xie et al.
    Cryo-EM and chemical cross-linking studies yield an atomic resolution structure of a conserved remodeling machinery in messenger ribonucleoprotein maturation/nuclear export and insights into its coordinated function with a serine‚Äďarginine protein.

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