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A calcineurin-mediated scaling mechanism that controls a K
-leak channel to regulate morphogen and growth factor transcription
Chao Yi et al.
Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
Immunology and Inflammation
Microbiology and Infectious Disease
CRISPR-based functional genomics in human dendritic cells
Marco Jost et al.
A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
A robust method for particulate detection of a genetic tag for 3D electron microscopy
James Rae et al.
Development of a new system for gold particle detection of a genetic tag for electron microscopy.
Chromosomes and Gene Expression
Co-regulation and function of
bidirectional genes in cancer
Carter J Barger et al.
FOXM1 is co-expressed with its bidirectional gene partner RHNO1, and the two genes promote DNA repair, cell growth and survival, and chemotherapy resistance in ovarian cancer.
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
David W Sanders et al.
A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.
Structural Biology and Molecular Biophysics
Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
Jordana K Thibado et al.
Homo- and heterodimeric group II metabotropic glutamate receptors show diverse modes of interaction between transmembrane domains that control their distinct assembly and activation properties.
An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma
Rediet Zewdu et al.
Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction
Eva On-Chai Lau et al.
DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells
Takashi Ogino et al.
The expression of the major circadian component CLOCK is a key regulator of stemness in breast cancer cells, which can be a novel strategy for breast cancer treatment.
Asprosin-neutralizing antibodies as a treatment for metabolic syndrome
Ila Mishra et al.
Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.
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