5,265 results found
    1. Microbiology and Infectious Disease

    SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

    Anna Z Mykytyn et al.
    Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

    Martina Brunati et al.
    Hepsin is the first protease identified to modulate specific cleavage and secretion of a Zona Pellucida domain protein, uromodulin.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding

    Hao Wang et al.
    N-glycans commonly present in the protease domains are required for calnexin-mediated protein folding and intracellular trafficking.
    1. Neuroscience

    Ultra-Rapid serial visual presentation reveals dynamics of feedforward and feedback processes in the ventral visual pathway

    Yalda Mohsenzadeh et al.
    Reducing visibility with higher image presentation rates increases recurrent processing demands along the visual processing pathway to resolve object recognition.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

    Niels Bradshaw et al.
    Structures of active and inactive conformations of a PP2C family phosphatase reveal a conserved switch that controls enzymatic activity and point to an unexpected relationship between phosphatases and proteasomal proteases.
    1. Microbiology and Infectious Disease

    PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM

    Sabrina Wamp et al.
    Analysis of suppressor mutants led to the identification of a novel signalling pathway that regulates peptidoglycan biosynthesis in Gram-positive bacteria.
    1. Chromosomes and Gene Expression

    Dual control of NAD+ synthesis by purine metabolites in yeast

    Benoît Pinson et al.
    Two distinct processes drive coordinated synthesis of purine and pyridine (NAD+) nucleotides in response to AICAR derivatives and ATP.
  1. Meta-Research: Journal policies and editors’ opinions on peer review

    Daniel G Hamilton et al.
    A survey of journals and editors in five areas of research - ecology, economics, medicine, physics and psychology - reveals a range of differences in their approach to peer review.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Sperm: The secrets of success

    Kayla M Komondor, Anne E Carlson
    Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level.
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    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.

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