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    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt, Matthew Robert Geoffrey Russell ... Moritz Treeck
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

    Clotilde Guyon, Nada Jmari ... Matthieu Giraud
    The Aire-dependent genes show a preference for short 3’UTR transcript isoforms resulting in the escape from the post-transcriptional repression mediated by miRNAs in medullary thymic epithelial cells.
    1. Cell Biology

    In vitro reconstitution of branching microtubule nucleation

    Ammarah Tariq, Lucy Green ... James G Wakefield
    Purification of two conserved protein complexes, the γ-TuRC and Augmin, using a simple affinity technique, demonstrates that they are necessary and sufficient for the essential phenomenon of branching microtubule nucleation.
    1. Cell Biology

    DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

    Brittany J Belin, Terri Lee, R Dyche Mullins
    An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.
    1. Cell Biology
    2. Neuroscience

    Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

    Blake A Creighton, Simone Afriyie ... Damaris N Lorenzo
    Giant ankyrin-B enables the transduction of Sema 3A repelling cues and is important for normal axonal connectivity.
    1. Neuroscience

    Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans

    Giulio Valperga, Mario de Bono
    Stimulus-receptivity loss increases coupling of a sensory neuron to a second sensory circuit by upregulating neuropeptide receptors, enhancing output of the second circuit, and providing a mechanism for cross-modal plasticity.
    1. Microbiology and Infectious Disease

    Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

    Ashelyn E Sidders, Katarzyna M Kedziora ... Brian P Conlon
    Palmitoleic acid not only potentiates vancomycin killing of Gram-positive bacteria, but the insertion of palmitoleic acid into the membrane leads to the unexpected accumulation of membrane-bound cell wall precursors, representing a novel mechanism of action for unsaturated fatty acids.
    1. Genetics and Genomics
    2. Neuroscience

    Genomic stability of self-inactivating rabies

    Ernesto Ciabatti, Ana González-Rueda ... Marco Tripodi
    SiR does not revert to wild type when produced in high-TEVp cell lines, is non-toxic in vivo, maintains transsynaptic spreading capabilities and revertant mutations do not accumulate during in vivo experiments.
    1. Microbiology and Infectious Disease

    WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae

    Josué Flores-Kim, Genevieve S Dobihal ... David Z Rudner
    Selective removal of Wall Teichoic Acids from the envelope of Streptococcus pneumoniae prevents bacteriolysis and directs zonal cell wall synthesis.
    1. Neuroscience

    High-fidelity musculoskeletal modeling reveals that motor planning variability contributes to the speed-accuracy tradeoff

    Mazen Al Borno, Saurabh Vyas ... Scott L Delp
    The speed-accuracy tradeoff could be a consequence of motor planning variability and not exclusively signal-dependent noise, as is currently held.