300 results found
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias et al.
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.
    1. Neuroscience

    Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

    Patrícia A Correia et al.
    Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren et al.
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Chromosomes and Gene Expression

    Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

    Jade Hebras et al.
    Knockout of Snord115 has mild impact on expression and function of the serotonin 2C receptor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Chemical and structural investigation of the paroxetine-human serotonin transporter complex

    Jonathan A Coleman et al.
    Structural and biochemical analysis of the mechanism of paroxetine binding to the serotonin transporter provides a framework for transporter inhibition and design of small-molecule inhibitors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors

    Yi-xiang Qi et al.
    Insects use serotonin signaling in blood cells to help defend themselves against pathogens.
    1. Cell Biology

    Serotonin signaling by maternal neurons upon stress ensures progeny survival

    Srijit Das et al.
    Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
    1. Neuroscience
    2. Computational and Systems Biology

    A specific role for serotonin in overcoming effort cost

    Florent Meyniel et al.
    A selective reuptake inhibitor shows a beneficial effect in healthy humans during an effort-benefit tradeoff task, mediated at the computational level by a specific alleviation of effort cost.
    1. Genetics and Genomics

    Drosophila serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

    Yang Lyu et al.
    Dietary choice per se is sufficient to modulate aging in Drosophila and through serotonergic control of peripheral metabolism.
    1. Neuroscience

    Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans

    Bo-mi Song et al.
    The nematode worm C. elegans consumes familiar bacterial species more rapidly than it does novel ones, and this preference for familiarity is mediated by a pair of serotonergic neurons.

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