228 results found
    1. Cell Biology

    Serotonin signaling by maternal neurons upon stress ensures progeny survival

    Srijit Das et al.
    Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren et al.
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Neuroscience

    Activity patterns of serotonin neurons underlying cognitive flexibility

    Sara Matias et al.
    Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.
    1. Neuroscience

    Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

    Patrícia A Correia et al.
    Phasic activation of dorsal raphe serotonin neurons transiently inhibits locomotion without influencing anxiety or producing reinforcement, but when repeated over many days a long-term facilitation of locomotion is produced.
    1. Neuroscience

    Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels

    Derya Sargin et al.
    Serotonin neurons in chronically isolated mice become less responsive to excitatory stimulation, but inhibiting a distinctive calcium-activated potassium channel can restore both neuronal activity and behavior.
    1. Neuroscience

    Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels

    Kara E Zang et al.
    Genetic analysis of how neuropeptides control C. elegans reproductive behavior shows how T-type calcium channels engage and disengage target neurons from these critical regulators of neural circuits and behavior.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    Serotonin: Slow motion

    Naoshige Uchida, Jeremiah Y Cohen
    Optogenetic stimulation of serotonin neurons in the dorsal raphe causes mice to move more slowly without causing any apparent motor deficits or anxiety-like effects.
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    1. Neuroscience

    Sleep homeostasis regulated by 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body of drosophila

    Yongjun Qian et al.
    Serotonergic signaling regulates sleep homeostasis through 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body in drosophila.
    1. Neuroscience

    Serotonergic neurons signal reward and punishment on multiple timescales

    Jeremiah Y Cohen et al.
    Serotonin-releasing neurons show tonic firing-rate changes correlating with global reward value in addition to phasic firing-rate changes correlating with local task events.

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