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    1. Cell Biology

    Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome

    Laura Childers, Jieun Park ... Michel Bagnat
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Trisomy 21 consistently activates the interferon response

    Kelly D Sullivan, Hannah C Lewis ... Joaquín M Espinosa
    Hyperactive interferon signaling is a hallmark of trisomy 21 and may contribute to many of the comorbidities associated with Down syndrome.
    1. Microbiology and Infectious Disease

    Robust manipulation of the behavior of Drosophila melanogaster by a fungal pathogen in the laboratory

    Carolyn Elya, Tin Ching Lok ... Michael Eisen
    A newly described isolate of the behavior-manipulating fly pathogen Entomophthora muscae that naturally infects fruit flies can be cultured in the lab, enabling molecular investigation of how microbes induce behavior changes in animal hosts.
    1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher
    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.
    1. Ecology
    2. Evolutionary Biology

    Seminal fluid compromises visual perception in honeybee queens reducing their survival during additional mating flights

    Joanito Liberti, Julia Görner ... Boris Baer
    After insemination, honeybee queens experience a rapid reduction in vision and flight performance, consistent with an ongoing sexual conflict over the number of mating flights that queens embark on.
    1. Neuroscience

    The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

    Christopher L Cunningham, Zizhen Wu ... Ulrich Müller
    Murine TOMT is essential for transport of mechanotransduction components to stereocilia in cochlear hair cells.
    1. Neuroscience

    Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability

    Xiaobo Jia, Jiemin Zhu ... Yi Rao
    Physiological studies of SLC6A17 and its pathogenic mutations revealed that glutamine is transported into synaptic vesicles (SVs) in an SLC6A17-dependent manner and all pathogenic conditions reduced glutamine level in SVs.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Reevaluation of Piezo1 as a gut RNA sensor

    Alec R Nickolls, Gabrielle S O'Brien ... Alexander T Chesler
    Piezo1 ion channels are not modulated by RNA ligands, contrary to previous findings.
    1. Neuroscience

    Dopaminergic challenge dissociates learning from primary versus secondary sources of information

    Alicia J Rybicki, Sophie L Sowden ... Jennifer L Cook
    Haloperidol comparably affects learning from social and non-social sources when they are the primary source of information but does not affect learning from (social or non-social) secondary sources, providing evidence in support of domain-general neurochemical mechanisms underpinning social learning.
    1. Medicine

    Bone circuitry and interorgan skeletal crosstalk

    Mone Zaidi, Se-Min Kim ... Tony Yuen
    Intracellular and interorgan skeletal crosstalk highlights integrative skeletal physiology.