Browse the search results

Page 3 of 716
    1. Developmental Biology

    Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

    Konstantinos Gkatzis, Paolo Panza ... Didier YR Stainier
    A serum-free organotypic culture model of mouse lung epithelial progenitors was developed and used to screen WNT modulators for regulators of epithelial differentiation.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Synergy between serum amyloid A and secretory phospholipase A2

    Shobini Jayaraman, Marcus Fändrich, Olga Gursky
    SAA removes toxic products of lipolysis of the cell membrane by sPLA2, indicating that SAA and sPLA2 act synergistically to clear debris from injured sites, as required for tissue healing.
    1. Microbiology and Infectious Disease

    Evolution of a functionally intact but antigenically distinct DENV fusion loop

    Rita M Meganck, Deanna Zhu ... Longping V Tse
    Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Medicine

    SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples

    Emanuela Abiusi, Paola Infante ... Francesco Danilo Tiziano
    The identification of SMA-miR supports the pathogenic role of skeletal muscle in spinal muscular atrophy and, integrated in the SMA-score, may help to improve the phenotypic prediction for patients.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    Jing Zhang, Zi Bo Han ... Qi Ming Li
    Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
    1. Immunology and Inflammation

    Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2

    Tong Feng, Qi Zhang ... Qiao-Feng Wu
    Serum exosomal sequencing combined with cell and animal experiments indicate that miRNA-199b-5p is a novel miRNA associated with osteoarthritis (OA) and can modulate the onset and progression of the disease.
    1. Medicine
    2. Microbiology and Infectious Disease

    The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

    Hsiao-Fan Chen, Wei-Jan Wang ... Mien-Chie Hung
    Two natural tannins, oligomeric proanthocyanidins and punicalagin, acted as potent inhibitors against SARS-CoV-2 infection, and grape seed extract supplementation could serve as a healthy food for infection prevention.
    1. Microbiology and Infectious Disease

    Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    Yang Fu, Xiao-Dan Luo ... Wence Wang
    Lactobacillus plantarum regulates host uric acid metabolism via its own nucleoside hydrolase iunH.
    1. Medicine

    Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

    Jeong-Oh Shin, Jong-Bin Lee ... Jin-Woo Kim
    rhPTH(1-34) and dimeric R25CPTH(1-34) significantly promoted bone regeneration and titanium implant osseointegration in an osteoporotic beagle model.
    1. Neuroscience

    SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

    Surya Chandra Rao Thumu, Monika Jain ... Narendrakumar Ramanan
    Serum response factor (SRF) deficient reactive astrocytes are neuroprotective in the mammalian brain.