7,356 results found
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty et al.
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

    Zhaoqing Zheng et al.
    Loss of MeCP2 function negatively impacts Tet1 and CTCF binding thereby negatively impacting learning-dependent DNA methylation and alternative splicing regulation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Heterochromatin assembly and transcriptome repression by Set1 in coordination with a class II histone deacetylase

    David R Lorenz et al.
    Set1 has roles in chromatin organization and transcriptome control that are largely independent of histone H3 lysine 4 methylation.
    1. Neuroscience

    A resource-rational theory of set size effects in human visual working memory

    Ronald van den Berg, Wei Ji Ma
    Set size effects in visual working memory are explained as a resource-rational trade-off between an error-based behavioral cost and a neural encoding cost.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals

    Lin Fu et al.
    Methylation of Gli3 by Set7 enhances the activation of Hedgehog signaling and contributes to tumor growth and metastasis in vitro and in vivo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

    Masahiro Oka et al.
    A key molecule that connects leukemogenic proteins to aberrant HOX gene regulation turned out to be a nuclear export factor, CRM1.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah et al.
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Human Biology and Medicine
    2. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson et al.
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Neuroscience

    Temporal chunking as a mechanism for unsupervised learning of task-sets

    Flora Bouchacourt et al.
    Model-based analyses of human behaviour and neural activity show that representations of concurrent task-sets emerge by merging together representations of individual stimulus-response associations that occur in temporal proximity.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

    Wenke Wang et al.
    Two SET-domain containing proteins regulate H3K4me3 by their binding to H3K4me3 through their PHD domain and directly regulate expression of a subset of genes.

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