Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
Gansheng Tan, Anna L Huguenard ... Eric C Leuthardt
Transcutaneous auricular vagus nerve stimulation is a safe neuromodulatory treatment for subarachnoid hemorrhage patients, with potential benefits for restoring autonomic balance.
High-throughput animal tracking and quantitative behaviour analysis detects diverse phenotypes in genetic disease models at a scale that makes drug screens possible.
Variants in FGF13, associated with developmental and epileptic encephalopathies, alter neuronal excitability by affecting inhibitory neurons and by a sodium channel-independent mechanism.
Timothy J Abreo, Emma C Thompson ... Edward C Cooper
A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
A new example of niche formation, revealing the mode of niche cell migration, implicates extrinsic sources of positional information, and uncovers the pathway required for stereotypical positioning of the niche.
