7,416 results found
  1. Meta-Research: A 10-year follow-up study of sex inclusion in the biological sciences

    Nicole C Woitowich et al.
    Sex-inclusive research practices have increased in many biological disciplines over the past decade, yet critical sex-based analyses and reporting have remained stagnant in most of these disciplines.
    1. Biochemistry and Chemical Biology

    Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

    Harunori Yoshikawa et al.
    Translationally active polysomes from mammalian cells/tissues are successfully separated with rapidity, high efficiency and exceptional reproducibility by a SEC-based approach, an accessible alternative to the conventional sucrose density gradient analysis.
    1. Genetics and Genomics

    Mutations primarily alter the inclusion of alternatively spliced exons

    Pablo Baeza-Centurion et al.
    Deep mutagenesis reveals that mutations rarely alter the inclusion of highly-included exons.
    1. Microbiology and Infectious Disease

    Single-cell transcriptional dynamics of flavivirus infection

    Fabio Zanini et al.
    A novel virus-inclusive single cell RNA-Seq approach enables identification of novel pro- and antiviral host factors in human cells in response to dengue and Zika virus infection.
    1. Developmental Biology
    2. Evolutionary Biology

    Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

    Judith Wexler et al.
    Sexual differentiation controlled by sex-specific mRNA splicing evolved in a step-wise manner in insects.
    1. Biochemistry and Chemical Biology

    SETD3 protein is the actin-specific histidine N-methyltransferase

    Sebastian Kwiatkowski et al.
    Histone-lysine N-methyltransferase SETD3 (NP_115609.2) was identified as the actin-specific histidine N-methyltransferase, an enzyme catalyzing the extremely well-conserved methylation of H73 in β-actin.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structural basis for the hijacking of endosomal sorting nexin proteins by Chlamydia trachomatis

    Blessy Paul et al.
    Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg et al.
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Neuroscience

    Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response

    Pinglei Bao et al.
    The lower-level retinotopic visual cortex of humans born without the optic chiasm comprises two independent neuronal populations and forms a versatile model for quantifying the relationship between the fMRI BOLD signal and neural response.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A dynamic mode of mitotic bookmarking by transcription factors

    Sheila S Teves et al.
    In contrast to published findings showing exclusion, transcription factors in fact bind mitotic chromosomes in a dynamic fashion, allowing for efficient transmission of transcription programs through mitosis.

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