1,129 results found
    1. Epidemiology and Global Health

    SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study

    Carlos A Prete Jr, Lewis F Buss ... Ester C Sabino
    Blood donor serosurveillance in eight of Brazil’s most populous cities reveals extensive variation of SARS-CoV-2 attack rate across cities, age, and sex groups in December 2020 and increased intrinsic severity of the Gamma variant of concern.
    1. Neuroscience

    Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior

    Emily A Bayer, Rebecca C Stecky ... Oliver Hobert
    The sex-specificity of a transcription factor required for sexual differentiation of a neural circuit is regulated by a novel post-transcriptional mechanism.
    1. Neuroscience

    Two single-point mutations shift the ligand selectivity of a pheromone receptor between two closely related moth species

    Ke Yang, Ling-Qiao Huang ... Chen-Zhu Wang
    Differing from its ortholog in Helicoverpa armigera, pheromone receptor HassOr14b is tuned to the major sex pheromone component in H. assulta, and two amino acids in the intracellular domain determine their ligand selectivity.
    1. Chromosomes and Gene Expression

    X-chromosome target specificity diverged between dosage compensation mechanisms of two closely related Caenorhabditis species

    Qiming Yang, Te-Wen Lo ... Barbara J Meyer
    Regulatory hierarchies controlling sex determination and X-chromosome dosage compensation between closely-related nematode species are conserved, but X-chromosome target specificity for the condensin dosage compensation complex has diverged, thereby contributing to reproductive isolation.
    1. Developmental Biology
    2. Evolutionary Biology

    Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

    Judith Wexler, Emily Kay Delaney ... Artyom Kopp
    Sexual differentiation controlled by sex-specific mRNA splicing evolved in a step-wise manner in insects.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans

    Charlotte P Choi, Rebecca J Tay ... John K Kim
    snpc-1.3 specifies male piRNA transcription and is regulated by the sex determination pathway.
    1. Genetics and Genomics
    2. Neuroscience

    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

    Colleen M Palmateer, Catherina Artikis ... Michelle N Arbeitman
    A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.
    1. Neuroscience

    Timing mechanism of sexually dimorphic nervous system differentiation

    Laura Pereira, Florian Aeschimann ... Oliver Hobert
    The timing of sexual differentiation in the brain of the nematode Caenorhabditis elegans is controlled by a phylogenetically conserved pathway of gene regulatory factors.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    High rates of evolution preceded shifts to sex-biased gene expression in Leucadendron, the most sexually dimorphic angiosperms

    Mathias Scharmann, Anthony G Rebelo, John R Pannell
    In the dioecious plant genus Leucadendron, shifts to sex-biased gene expression occurred predominantly in genes with ancestrally high rates of expression evolution, and were not correlated with morphology.
    1. Medicine

    Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

    Gretchen A Meyer, Stavros Thomopoulos ... Karen C Shen
    Blocking an atrophic 'master regulator' pathway following tendon tear does not affect resulting skeletal muscle atrophy.

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