During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.

A spatially-tuned normalization model accounts for neuronal responses to attended or unattended stimuli that are presented inside the classical receptive field or the surround, and explains various other observations.

Job insecurity is putting stress on early-career researchers in Australia, compromising their career development and potentially reducing the quality of research.

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.

First experimental studies on the ion atmosphere around a nucleosome provide a quantitative analysis of the molecule's electrostatic properties.

RELION-3 calculates single-particle reconstructions to higher resolution and with less user-interactions than previously available versions.

The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.

Echolocating bats may recognize locations in the environment (and navigate to them) by remembering the specific echo signature of those locations.

Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.

Post-refinement methods enable the use of X-ray free electron lasers for biological crystallography of systems in which sample quantity is a limitation.