142 results found
    1. Neuroscience

    Uncovering temporal structure in hippocampal output patterns

    Kourosh Maboudi et al.
    Machine learning models of coordinated hippocampal ensemble activity during sharp wave ripple activity encode structure that mirrors the place cell map expressed during exploration, and enable a new paradigm for analyzing and understanding this offline activity.
    1. Neuroscience

    Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility

    Jai Y Yu et al.
    During awake Sharp wave-ripple memory reactivation, hippocampal-cortical representations for movement- versus immobility-associated experiences are reactivated separately.
    1. Neuroscience

    Cell-specific synaptic plasticity induced by network oscillations

    Shota Zarnadze et al.
    Recordings of cellular and network activities of the mouse brain provide insights into how gamma rhythms contribute to memory formation.
    1. Neuroscience

    Hippocampus: Getting the full picture

    Alessandro Luchetti et al.
    A combination of old and new techniques have been used to reveal new details about the behavior of individual neurons across the sleep-wake-cycle.
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    1. Computational and Systems Biology

    Meta-Research: Centralized scientific communities are less likely to generate replicable results

    Valentin Danchev et al.
    Analysis of data on drug-gene interactions suggests that decentralized collaboration will increase the robustness of scientific findings in biomedical research.
  1. Point of View: Four erroneous beliefs thwarting more trustworthy research

    Mark Yarborough et al.
    Strategies to improve public trust in biomedical research are being hindered by a scientific mindset that stifles interest in reform.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Point of View: The challenges faced by living stock collections in the USA

    Kevin McCluskey et al.
    Living stock collections provide invaluable resources to research communities, yet they face significant challenges.
    1. Neuroscience

    Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus

    Francois M Lambert et al.
    Molecular labeling, electrophysiology and calcium imaging have revealed a novel switching of neurotransmitter at the frog neuromuscular junction where motoneurons transiently release glutamate before acetylcholine at synapses on developing hindlimb muscles at the onset of metamorphosis.
    1. Developmental Biology
    2. Evolutionary Biology

    An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

    David S Lorberbaum et al.
    The seemingly simple, constitutive response of the patched/Ptch1 gene to Hedgehog signaling is in fact regulated by large batteries of context-specific Hedgehog-responsive enhancers in both fly and mouse, allowing tissue-specific tuning of the Hedgehog pathway in animal development and evolution.
    1. Neuroscience

    Retroactive modulation of spike timing-dependent plasticity by dopamine

    Zuzanna Brzosko et al.
    Dopamine, a reward signal in the brain, can retroactively convert hippocampal synaptic depression into potentiation, suggesting an elegant biological solution to the distal reward problem.

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