145 results found
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan Shugarts, Aishwarya Sathya ... Antony M Jose
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity

    Gurmeet Kaur, A Maxwell Burroughs ... L Aravind
    Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
    1. Neuroscience

    A unified neural account of contextual and individual differences in altruism

    Jie Hu, Arkady Konovalov, Christian C Ruff
    Individual and situational differences in altruistic behavior do not reflect use of fundamentally different decision mechanisms, but instead differences in early perceptual or attentional processing of the choice-relevant information.
    1. Evolutionary Biology

    Tradeoff breaking as a model of evolutionary transitions in individuality and limits of the fitness-decoupling metaphor

    Pierrick Bourrat, Guilhem Doulcier ... Katrin Hammerschmidt
    A new model describes evolutionary transitions in individuality in terms of tradeoff and tradeoff-breaking events as opposed to changes in the nature of fitness.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Symbiont-mediated cytoplasmic incompatibility: What have we learned in 50 years?

    J Dylan Shropshire, Brittany Leigh, Seth R Bordenstein
    This review serves as a gateway to experimental, conceptual, and quantitative themes of cytoplasmic incompatibility (CI) and outlines significant gaps in the understanding of CI's mechanism that are ripe for investigation.
    1. Neuroscience

    Towards a Neurometric-based Construct Validity of Trust

    Pin-Hao A. Chen, Dominic Fareri ... Luke J. Chang
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology

    Neural arbitration between social and individual learning systems

    Andreea Oliviana Diaconescu, Madeline Stecy ... Philippe N Tobler
    Arbitration is formalised as the relative precision of predictions afforded by reward and social learning systems and is represented in modality-specific dopaminergic and dopaminoceptive regions, including the midbrain and amygdala.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

    Whitney L Johnson, William T Yewdell ... Aaron F Straight
    SUV39H1 histone methyltransferase directly binds chromosome associated RNA to promote constitutive heterochromatin formation.
    1. Neuroscience

    A neurocomputational account of the link between social perception and social action

    Lisa M. Bas, Ian D. Roberts ... Anita Tusche
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

    Claudia D Consalvo, Adedeji M Aderounmu ... Brenda L Bass
    Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.

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