130 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Transcriptional control of compartmental boundary positioning during Drosophila wing development

    Gustavo Aguilar, Michèle Sickmann ... Martin Müller
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Neuroscience

    Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons

    Yasutetsu Kanaoka, Koun Onodera ... Yukako Hattori
    A muscle-derived Wnt signal promotes dendritic branching of somatosensory neurons in response to a concurrent deficiency in vitamins, minerals, and cholesterol.
    1. Chromosomes and Gene Expression

    Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins

    Steven Z DeLuca, Megha Ghildiyal ... Allan C Spradling
    Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.
    1. Ecology
    2. Plant Biology

    Cytokinin transfer by a free-living mirid to Nicotiana attenuata recapitulates a strategy of endophytic insects

    Christoph Brütting, Cristina Maria Crava ... Ian T Baldwin
    Cytokinin-dependent manipulation of plant metabolism is a strategy employed not only by gallers and leaf-miners but also by a free-living insect, Tupiocoris notatus, which directly transfers cytokinins at feeding sites to manipulate its host plant.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

    Marisa S Egan, Emily A O’Rourke ... Sunny Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Ecology

    Binding and sequestration of poison frog alkaloids by a plasma globulin

    Aurora Alvarez-Buylla, Marie-Therese Fischer ... Lauren A O'Connell
    Alkaloid-binding globulin (ABG) is a novel protein discovered in the plasma of poison frogs that transports many alkaloids, with structural homology to mammalian hormone carriers and amphibian biliverdin-binding serpin.
    1. Cancer Biology
    2. Genetics and Genomics

    A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes

    Eli M Carrami, Sahand Sharifzadeh ... Ahmed A Ahmed
    A robust library preparation and variant calling strategy (DigiPico/MutLX) eliminates false positive single nucleotide variants from picogram quantities of DNA following whole genome amplification.
    1. Cell Biology
    2. Neuroscience

    Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

    Belgin Yalçın, Lu Zhao ... Cahir J O'Kane
    Proteins of the reticulon and REEP families, homologous to the products of human Hereditary Spastic Paraplegia disease genes, contribute to shaping and continuity of the axonal endoplasmic reticulum network in Drosophila.
    1. Cell Biology

    A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

    David B Heisler, Kristen A Johnson ... Arun Radhakrishnan
    An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.

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