403 results found
    1. Plant Biology
    2. Evolutionary Biology

    Herbivory-induced volatiles function as defenses increasing fitness of the native plant Nicotiana attenuata in nature

    Meredith C Schuman, Kathleen Barthel, Ian T Baldwin
    A 2-year field study has demonstrated that volatile compounds produced by plants when they are attacked by herbivores act as defenses by attracting predators to the herbivores and increasing the reproduction of the plants.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

    Bray Denard, Ching Lee, Jin Ye
    Cleavage of a membrane-bound transcription factor by the chemotherapeutic reagent doxorubicin can block the proliferation of tumor cells.
    1. Structural Biology and Molecular Biophysics

    De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy

    Deryck J Mills, Stella Vitt ... Janet Vonck
    The structure of a large hydrogenase complex involved in the production of methane by microbes has been determined with cryo-electron microscopy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

    Florian Wilfling, Abdou Rachid Thiam ... Tobias C Walther
    The targeting of proteins from the endoplasmic reticulum to lipid droplets relies on surface modulation of the lipid droplet by the Arf1/COPI machinery.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Sex-specific triacylglycerides are widely conserved in Drosophila and mediate mating behavior

    Jacqueline SR Chin, Shane R Ellis ... Joanne Y Yew
    Triacylglycerides found in the males of 11 species of Drosophila form a largely overlooked, novel, sex-specific class of pheromones that act to suppress courtship behaviour.
    1. Cell Biology

    A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

    Lori Clay, Fabrice Caudron ... Yves Barral
    Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.
    1. Cell Biology

    Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

    Scott J Dixon, Darpan N Patel ... Brent R Stockwell
    Erastin and sorafenib inhibit system xc- and induce ER stress, suggesting these may be useful tools for probing the functions of system xc- and its role in inducing ER stress and ferroptosis.
    1. Biochemistry and Chemical Biology

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo, Patricia Marmol ... Carlos F Ibanez
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern, Diana Langer ... Irwin Davidson
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.

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