897 results found
    1. Neuroscience

    Protein kinase C is a calcium sensor for presynaptic short-term plasticity

    Diasynou Fioravante et al.
    Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.
    1. Neuroscience

    Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

    Kevin Dorgans et al.
    Molecular, structural and functional diversity of cerebellar granule cell inputs on single molecular layer interneurons extends information processing in feed-forward inhibition microcircuits.
    1. Neuroscience

    Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity

    Jennifer M Ortega et al.
    Genetic and electrophysiological experiments define how homeostatic signaling stabilizes both the gain and short-term dynamic properties of neurotransmitter release, ensuring that synaptic information transfer remains robust to external perturbation.
    1. Neuroscience

    Recurrent network model for learning goal-directed sequences through reverse replay

    Tatsuya Haga, Tomoki Fukai
    The combination of short-term and long-term plasticity enables hippocampus to learn goal-directed paths through replay in a reversed order.
    1. Neuroscience

    Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts

    Mathan K Raja et al.
    Synaptophysins and gyrins dampen synaptic strength selectively at low frequencies, hinting that synaptic transmission may play a frequency filtering role in biological computation that is more general than currently envisioned.
    1. Neuroscience

    Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

    Stephanie C Seeman et al.
    A high-throughput pipeline for the characterization of cortical connectivity in mouse and human cortex.
    1. Neuroscience

    Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity

    Frédéric Doussau et al.
    The mobilization or silencing of two heterogeneous pools of synaptic vesicles via different frequencies probably enables granule cell to Purkinje cell synapses to better discriminate between the high-rate code of sensory information and background noise.
    1. Neuroscience

    Short-term synaptic dynamics control the activity phase of neurons in an oscillatory network

    Diana Martinez et al.
    The phase of a neuron in an oscillatory network can remain independent of network frequency when synaptic input strength and peak phase are adjusted in a frequency-dependent manner.
    1. Neuroscience

    NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus

    Andrea L Hartzell et al.
    Behaviorally-driven expression of the immediate early gene transcription factor NPAS4 changes local circuit connectivity and short-term plasticity by selectively recruiting CCK basket cell synapses to pyramidal neuron somas.

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