Small changes to the way COVID-19 vaccine side-effect rates are framed and communicated have meaningful impacts on individuals' vaccination intentions.

Estrogen receptor alpha in the hypothalamus is required for the effects of chronic tamoxifen treament on gene expression, thermoregulation, bone, and movement in mice.

In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.

Focal optogenetic inactivation of cortex induces complex changes in neural responses outside the targeted area that can influence behavioral performance.

A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.

The mechanism identified here that mediates olanzapine-induced b-cell dysfunction should be considered, along with weight gain, in mitigating adverse side effects when patients with schizophrenia are prescribed olanzapine.

Emerging approaches in larval zebrafish to identify safe opioid therapies without the side-effect of respiratory depression.

Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

The kinetics of actin polymerization are strongly influenced by the binding of proteins to the lateral filament surface.