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A genetically diverse panel of subject-specific induced pluripotent stem cells models the in vitro susceptibility of cardiac cells to develop a cardiotoxic drug response.

Sphinganine-1-phosphate (SA1P) is linked to paclitaxel-induced peripheral neuropathy, offering a potential target for reducing this severe side effect of paclitaxel treatment.

Interplay between multiple Legionella pneumophila effector proteins lead to spatial and temporal regulation of the host Rab10 localization to the bacterial vacuole by controlling noncanonical ubiquitin modifications.

Protein conformational heterogeneity changes upon ligand binding are influenced by ligand properties and can modulate the free energy of binding.

Careful analysis of a database populated by physicians and patients sheds new light on the side effects of drugs.

Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.

Sequence-variant analogs of mitochondria-targeted tetrapeptides have distinct patterns of membrane-bound conformations, effects on membrane properties, and abilities to protect mitochondria subject to stress, illuminating how side chain variation can be leveraged in the development of more effective therapeutic compounds.

Careful analysis of adverse drug reaction reports reveals noise and biases embedded in this data and allows for systematic mitigation of these effects to produce much more robust understanding of side effects of marketed drugs.

Introduction of single photoswitchable unnatural amino acid into a neuronal receptor provides reversible, rapid and robust control of its activity by light, representing an important contribution to the fast expanding field of optopharmacology.

The pattern of spatial attention preferences in caudate neurons is altered by superior colliculus inactivation, demonstrating that a superior colliculus to basal ganglia link is important for selective attention.