9,720 results found
    1. Neuroscience

    Attention modulates human visual responses to objects by tuning sharpening

    Narges Doostani, Gholam-Ali Hossein-Zadeh ... Maryam Vaziri-Pashkam
    Attentional modulation is affected by target-distractor similarity, indicating tuning sharpening as the underlying mechanism for response enhancement during object-based attention.
    1. Neuroscience

    Evaluating hippocampal replay without a ground truth

    Masahiro Takigawa, Marta Huelin Gorriz ... Daniel Bendor
    A novel tool enables cross-checking the quality of replay events and evaluating the effectiveness of a given replay detection method in the absence of a ground truth.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Sweepstakes reproductive success via pervasive and recurrent selective sweeps

    Einar Árnason, Jere Koskela ... Bjarki Eldon
    Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
    1. Cancer Biology

    Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

    Aojia Zhuang, Aobo Zhuang ... Chen Ding
    Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
    1. Neuroscience

    The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

    Abraham Katzen, Hui-Kuan Chung ... Shawn R Lockery
    A worm with a nervous system of only 302 neurons satisfies the necessary and sufficient conditions for value-based decision making.
    1. Neuroscience

    A model of hippocampal replay driven by experience and environmental structure facilitates spatial learning

    Nicolas Diekmann, Sen Cheng
    A model of hippocampal replay is proposed that gives a biologically plausible account of how the hippocampus could prioritize replay and produce a variety of different replay statistics, and is efficient in driving spatial learning.
    1. Neuroscience

    Network dynamics underlying OFF responses in the auditory cortex

    Giulio Bondanelli, Thomas Deneux ... Srdjan Ostojic
    Computational modeling demonstrates that population dynamics of neural calcium activity following stimulus offset are consistent with a network mechanism based on recurrent interactions.
    1. Developmental Biology
    2. Genetics and Genomics

    MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

    Meltem Weger, Benjamin D Weger ... Thomas Dickmeis
    The glucose-sensing transcription factor MondoA regulates zebrafish epiboly via cholesterol biosynthesis genes including the human disease gene Nsdhl, revealing an unknown role for metabolic glucose signalling in vertebrate development.
    1. Neuroscience

    Cortical adaptation to sound reverberation

    Aleksandar Z Ivanov, Andrew J King ... Nicol S Harper
    The auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to reduce the effects of reverberation.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pathway dynamics can delineate the sources of transcriptional noise in gene expression

    Lucy Ham, Marcel Jackson, Michael PH Stumpf
    There are fundamental limits to what can be learned about the origins of transcriptional noise from gene expression data alone, which can be overcome by simultaneously quantifying the abundances of linked molecular species.

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