2,020 results found
    1. Neuroscience

    Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'

    Benjamin Roland et al.
    Inhibitory circuits in the olfactory bulb can amplify or suppress sensory inputs over a wide range of intensities to generate robust mitral cell output.
    1. Neuroscience

    Adaptation of spontaneous activity in the developing visual cortex

    Marina E Wosniack et al.
    To generate stable and robust connectivity refinements, the amplitude of spontaneous activity events in the developing visual cortex adapts to the recent history of cortical activation.
    1. Cell Biology
    2. Computational and Systems Biology

    A quantitative approach for analyzing the spatio-temporal distribution of 3D intracellular events in fluorescence microscopy

    Thierry Pécot et al.
    QuantEv is a fully automatic and semi-parametric method that allows quantitative analysis of the spatio-temporal distribution of complex molecular trafficking objects at the scale of the whole cell.
  1. Meta-Research: Gender variations in citation distributions in medicine are very small and due to self-citation and journal prestige

    Jens Peter Andersen et al.
    In studies of gender disparities in academia, increased focus is required on within-group variability and between-group overlap of distributions when interpreting and reporting results.
    1. Neuroscience

    Retrieval practice facilitates memory updating by enhancing and differentiating medial prefrontal cortex representations

    Zhifang Ye et al.
    Retrieval practice strongly engages the medial prefrontal cortex to integrate and differentiate memory representations, resulting in more effective memory updating.
    1. Ecology
    2. Microbiology and Infectious Disease

    Transparent soil microcosms for live-cell imaging and non-destructive stable isotope probing of soil microorganisms

    Kriti Sharma et al.
    Two optically transparent substrates enable the exploration of the ecophysiology and spatiotemporal organization and activities of bacteria and fungi within heterogeneous soil-like environments.
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm et al.
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Neuroscience

    Neuropathological and transcriptomic characteristics of the aged brain

    Jeremy A Miller et al.
    High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
    1. Chromosomes and Gene Expression

    Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

    Li Zhou et al.
    Selective degradation of mature miRNAs shapes temporal miRNA expression patterns and is important for proper regulation of target genes to support normal development of Drosophila embryos.
    1. Cell Biology

    Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

    King Faisal Yambire et al.
    Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.

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